I ran the 222/250 for a year and now run the 333/332/250. I never had the NPX 300 on the 222, but if I were buying new I would spend a bit more and start with the 333/332 over the 222/300. The 222 is still tremendous on its own and a terrific value for an all in one.
When I first swapped from the 222 to the 332 I ran many different sources over the course of 6 months or so until I found a good used deal on the 333. I would suggest anyone thinking of buying the 332 to consider the 333 an absolute must. It’s a tremendous source that is a perfect match for the 332.