I have NDX2/XPSDR into 52/SC/300DR in one system, though I used it without the XPSDR for a while.
I have ND5XS2 (no nDAC) into 82/HC/250 in a different house. I did some mixing and matching before shipping that lot off to sunny Tasmania. If I changed anything in that system and could tolerate more boxes, the change would be adding an nDAC, but so far I have resisted.
I think @IainO is dead right. There are several threads worth reading, but the NDX2 is a very good player made much better with its PS (more depth, more detail, more sudden attack, more grip on bass). The ND5XS2 is much better VFM than an NDX2 and a pretty good player in absolute terms, but noticeably less good than NDX2 into my 52 for SQ.
With the 82, the gap between the 2 naked players was non-zero but really not huge - until we put the PS back on the NDX2.
Several people have commented that the a naked NDX2 is not significantly better than ND5XS2 plus nDAC, and that ND5XS2 plus nDAC plus XPSDR is slightly better than a naked NDX2, though different.
Few (not none) rate ND5XS2 plus nDAC plus XPSDR as being just as good as NDX2 plus XPSDR, and very few think the 3-box option is completely outclassed.
There are many here that stress Source First, and with reason. However, much though I like 82 (and the very comparable 282) plus 180, I am not sure you will find that 3-box option or NDX2 +XPSDR much different, and you may well decide that ND5XS2+nDAC or naked NDX2 is as far as you need to go.
A case can even be made to get ND5XS2 first, then add nDAC, and then leave PS options alone until you have swapped the 180 for a (serviced) 250.
VFM is also relevant. nDACs are not always easy to find but they are real bargains at £1K or sometimes even less. 250s are easy to find and also bargains - but do get one that was serviced in the last decade or so or priced accordingly. ND5XS2s are great value at under £2K on eBay - an NDX2 s/h will cost twice that. An XPS looks to be just over £1K but an XPDSR still looks to cost well over £2K.
It is also worth thinking about box count. Even if ND5XS2 + nDAC + XPS is the best VFM and ND5XS2 +nDAC + XPSDR is second best in sound-per-pound, and even if you find either beating a naked NDX2 into an 82/ 180 (or 82/250) by enough that you notice, do you want 3 boxes as your source? And do you care about remote controls and screens?
Finally,@Guido71 is not wrong in rating the old NDS for SQ and VFM. However, if you want Qobuz supported, I think you may need something more modern.