I take one of the pocket compact Olympuses when on holiday, supplemented by my iPhone. I only take the Canon when going somewhere where I know I want to try to capture really good shots, when choice of lens depends on where going, either taking just one, or limiting to two, carried on my waist in a Thinktank bumbag type bag. However on a safari I did last year swapping between the 100-400 outside the bush and 24-105 when we went in, I wished I’d also taken my wideangle because even 24mm was too long a focal length when a charging elephant stopped just in front of the vehicle(!), whilst at times I wished I had longer than 400.
I’ve never had the luxury of two camera bodies (I sold my previous 550D to part fund the R - perhaps I should have kept it, but that would be more bulk and weight to carry).
Just remembered I posted more info about my cameras in the previous “show us your cameras” thread: